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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE201136 | GEO | 2022/04/27

REPOSITORIES: GEO

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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [RNA-seq]

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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [ChIP-seq]

Project description:To understand the role of TH target genes in BAT, we developped a murine transgenic model which expressed a tagged-form of the thyroid hormone receptor alpha (TRa1, tagged with GS which is a fusion between protein G and streptavidin) specifically in brown adipocytes. Combined with RNAseq data, it allowed to establish the direct target genes of thyroid hormones (TH) in brown adipocytes

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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors

Project description:Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors

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Target genes of thyroid hormone (TH) in white adipose tissue (WAT) and striatum and their role during metabolic stressors

Project description:We gathered in a single database available RNAseq and ChIPseq data to better characterize the target genes of the thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of the hormone. Also, it is an easy-handling convenient tool to obtain information on specific genes in regards to T3 regulation, or extract larger list of genes of interest based on the users’ criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on thyroid hormones, their receptors, mode of action, targets and roles which may profit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes which transcription is upregulated by chromatin-bound nuclear receptor. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of hormonal response.

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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [RNA-seq]

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Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.

Project description: Not available

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Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis--A Cohort Study in a Group of Thyroid Carcinoma Patients.

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Brown Adipose Tissue (BAT) in Visceral Fat Depot

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