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Next-generation sequencing analysis of wild-type and PGRN-/- mouse neutrophils challenged with Candida albicans [RNA-seq]

ABSTRACT: To investigate the effect of Progranulin on neutrophils phagocytosis and killing of Candida albicans, we designed RNA-Seq analysis of wild-type and PGRN-/- neutrophils challenged with Candida albicans in vitro at one time point.

ORGANISM(S): Mus musculus

PROVIDER: GSE201166 | GEO | 2022/09/13

REPOSITORIES: GEO

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Next-generation sequencing analysis of wild-type and PGRN-/- mouse macrophages challenged with Candida albicans [RNA-seq]

Project description:To investigate the effect of progranulin on macrophages phagocytosis and killing of Candida albicans, we designed RNA-Seq analysis of wild-type and PGRN-/- macrophages challenged with Candida albicans in vitro at one time point.

2022-09-13 | GSE201165 | GEO

The Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Project description:<p>Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is not well understood, our study highlights a perspective in AnxA1 as a target protein in control the immune response during fungi infection. C57BL/6 wild-type (WT) and AnxA1 knockout (AnxA1-/-) peritoneal neutrophils were coinfected with Candida albicans or Candida auris for 4 hours. High levels of COX-2 were observed in WT and AnxA1-/- neutrophils infected with C. albicans and C. auris coinfection. In addition, AnxA1-/- neutrophils exhibited a marked increase of phosphorylated ERK, p-38 and JNK levels after coinfection with both Candida spp. Lipidomics approach shows that lack of AnxA1 produced a marked difference in lipid profile of control or coinfected neutrophil supernatants compared to WT, especially glycerophospholipids and glycerolipids. In summary, our results showed that endogenous AnxA1 regulates neutrophil response under fungal infection and its lipid membrane organization and metabolism.  </p>

2021-12-03 | MTBLS2288 | MetaboLights

Candida albicans phagocytosed by macrophages: intact vs. ruptured phagosomes

Project description:Transcriptional profiling of Candida albicans after 3 h phagocytosis by vehicle DMSO-treated macrophages (intact, expanding phagosomes) or calcium chelator BAPTA-AM-treated macrophages (inhibits lysosomal repair of expanding phagosomes, leading to phagosome rupture) to determine the effect of preventing phagosome expansion on C. albicans gene expression after phagocytosis by macrophages. Cultivation of Candida only for 3 h in DMEM-FBS cell culture medium or YPD complex medium as non-phagocytosis control conditions.

2020-10-05 | GSE147207 | GEO

Transcription profiling of human neutrophils cultured alone or with opsonized Candida albicans

Project description:Neutrophils were separated from human blood. Then they were either cultured alone or with opsonized Candida albicans (strain CAF2-1) for 2 hours in RPMI1640 at 37 deg C.

2007-05-31 | E-MEXP-914 | biostudies-arrayexpress

Candida albicans

Project description:Transcriptional Response of Candida albicans Cells Following Phagocytosis by Mouse Macrophages

| PRJNA106527 | ENA

Candida albicans

Project description:Candida albicans

| PRJNA308106 | ENA

Candida albicans

Project description:Candida albicans Sequencing

| PRJNA327830 | ENA

Comparative genomic hybridization of Candida albicans and Candida dublinienis

Project description:Comparative genomic hybridisation between Candida albicans and Candida dublinienis using Eurogentec Candida albicans whole genome microarrays

2004-04-30 | E-MEXP-99 | biostudies-arrayexpress

Candida albicans: control vs. alpha1-antitrypsin (AAT) treatment

Project description:Transcriptional profiling of Candida albicans SC5314 comparing C. albicans grown in RPMI1640 or in RPMI1640 with 100ug/ml AAT. Goal was to determine the effects of AAT on global C. albicans gene expression.

2023-01-01 | GSE165326 | GEO

Candida albicans: Control vs. sulfite-treated cells

Project description:Transcriptional profiling of Candida albicans cells comparing control untreated C. albicans cells with sulfite-treated C. albicans cells. Sulfite is a toxic molecule that C. albicans encounters in its human host. Both wild type and ∆zcf2 mutant cells were used. The goal was to determine the effects of sulfite on C. albicans gene expression, and to determine which of the genes areZcf2-depedent.

2016-12-03 | GSE90819 | GEO

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