Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 RNA-seq]

ABSTRACT: We identified DBC1/CCAR2 target genes using RNA-seq analysis in colon cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE201363 | GEO | 2022/08/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [RNA-seq]

Project description:We identified DBC1/CCAR2 target genes using RNA-seq analysis in colon cancer cells.

2022-08-17 | GSE179462 | GEO

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300.

Project description:Genome-wide maps of DBC1, KMT2D, and p300 in SW480 WT and DBC1 KO cells

2022-08-17 | GSE202478 | GEO

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 ChIP-seq]

Project description:Genome-wide maps of H3K4me3 and H3K27ac in HCT116 WT and DBC1 KO cells

2022-08-17 | GSE201362 | GEO

DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300.

Project description:Histone modification is a key epigenetic mechanism for regulation of chromatin dynamics and gene expression. Deleted in breast cancer 1 (DBC1) has been shown to act as a negative regulator of epigenetic modifiers and as a co-activator for nuclear receptors and other transcription factors. However, little is known about the role of DBC1 in the regulation of histone modifications and chromatin landscapes. Here, we analyzed genome-wide profiles of active enhancer and promoter marks in colorectal cancer cells and report DBC1 as a critical positive regulator of histone epigenetic writers KMT2D (H3K4 methyltransferase) and p300 (histone acetyltransferase). DBC1 is required for establishing the landscape of active enhancers, for genome-wide chromatin binding and enhancer recruitment of KMT2D and p300, and for gene activation involved in colorectal cancer progression. DBC1 interacts directly with KMT2D and p300, and enhances KMT2D-mediated histone H3K4 methylation (H3K4me1/2/3) and p300-mediated H3 acetylation. Importantly, DBC1 contributes to super-enhancer formation and function by facilitating the recruitment of KMT2D and p300 and by enhancing their functional interaction and cooperative cross-talk. Our results highlight the critical role of DBC1 as a key positive regulator of KMT2D and p300, and provide insights into regulatory mechanisms underlying the interplay between the enhancer epigenomic writers in enhancer activation.

| S-EPMC9371912 | biostudies-literature

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [ChIP-Seq]

Project description:Genome-wide maps of H3K4me3, H3K4me1, H3K27ac, H3K9/K14ac, and H3K4ac in SW480 WT and DBC1 KO cells

2022-08-17 | GSE179461 | GEO

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300

Project description:DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300

| PRJNA743890 | ENA

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300.

Project description:DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300.

| PRJNA836274 | ENA

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-17 | GSE179463 | GEO

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 RNA-seq]

Project description:DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 RNA-seq]

| PRJNA831098 | ENA

DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 ChIP-seq]

Project description:DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 ChIP-seq]

| PRJNA831099 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data