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BiCCA: Bi-order multiomics integration of single-cell data

ABSTRACT: Chimeric antigen receptor (CAR) engineering of NK cells is an active area of research with early-phase clinical studies showing an excellent safety profile with encouraging clinical responses. However, the transcriptional signatures that control the fate of CAR-NK cell after infusion and their association with tumor control remain poorly understood. Here, we performed single-cell RNA sequencing (scRNA-seq) to depict the evolution of various engineered CAR-NK cells Single cell RNA sequencing (scRNA) has revolutionized high-thoughout systems-based analysis of cellular and functional heterogeneity, The goals of this work are to compare transcriptome profiling (RNA-seq).

ORGANISM(S): Mus musculus

PROVIDER: GSE201491 | GEO | 2022/04/28

REPOSITORIES: GEO

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