Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities

ABSTRACT: Here we aim to decipher the actions of Irx5 in the regulation of obesity and metabolic abnormalities. We employed a mouse model homozygous for an Irx5-knockout (Irx5KO) allele and conducted droplet based single-cell RNA sequencing (Drop-seq) in the hypothalamic arcuate-median eminence (ARC-ME), which is the main control center for sensing and integrating feeding regulatory signals.

ORGANISM(S): Mus musculus

PROVIDER: GSE201736 | GEO | 2022/09/19

REPOSITORIES: GEO