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RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE201893 | GEO | 2025/04/28

REPOSITORIES: GEO

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RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.

Project description:The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of considerable importance for cellular signaling pathways. Recently, RNA-binding motif protein 47 (RBM47) has been suggested to function as a tumor regulator by acting as an RNA binding protein (RBP), but its role in HCC remains ambiguous. Here, in HCC, we identified that RBM47 had an inhibitory influence on tumor behaviors in vitro and accordingly suppressed the growth and metastasis of xenograft tumors in vivo. Additionally, RBM47 was verified to positively regulate Upframeshift 1 (UPF1), which is a crucial protein involved in the nonsense-mediated RNA decay (NMD) process and was previously determined to be an HCC suppressor. Mechanistically, the stability of UPF1 mRNA was demonstrated to be enhanced with its 3'UTR bound by RBM47, which acted as an RNA binding protein. Meanwhile, RBM47 was also proven to promote the transcription of UPF1 as a transcription factor. Taken together, we concluded that RBM47 functioned as a tumor suppressor by upregulating UPF1, acting as a DNA/RNA binding protein at the transcriptional and posttranscriptional levels.

| S-EPMC9279423 | biostudies-literature

RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator [RIP-seq]

Project description:By RIP sequencing, we determined that RBM47 modulated UPF1 by stabilizing its mRNA and addressed the novel motif in the UPF1 3’UTR with direct binding.

2025-04-28 | GSE201892 | GEO

RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator [ChIP-seq]

Project description:After ChIP assay, DNA sequencing was conducted to analyze the specific loci binding by RBM47 in HCCLM3 cells.

2025-04-28 | GSE201818 | GEO

RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator

Project description:RBM47 Inhibits Hepatocellular Carcinoma Progression as a DNA/RNA Regulator

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