Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

EHF and CDX1 co-operate to drive extensive transcriptional reprogramming and chromatin remodelling in CRC cells [RNA-seq]

ABSTRACT: EHF and CDX1 co-operate to drive differentation of CRC cells. To identify the transcriptional changes induced by these transcription factors, EHF and CDX1 were stably re-expressed in poorly differentiated HCT116 CRC cells and RNA sequencing analysis performed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE202073 | GEO | 2022/11/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

EHF and CDX1 co-operate to drive extensive transcriptional reprogramming and chromatin remodelling in CRC cells [ATAC-seq]

Project description:EHF and CDX1 co-operate to drive differentation of CRC cells. To identify the change in chromatin remodelling induced by these transcription factors, EHF and CDX1 were stably re-expressed in poorly differentiated HCT116 CRC cells and ATAC-seq analysis performed.

2022-11-02 | GSE202072 | GEO

EHF and CDX1 co-operate to drive extensive transcriptional reprogramming and chromatin remodelling in CRC cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-11-02 | GSE202074 | GEO

Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1

Project description:This study is to identify downstream targets of homeobox gene CDX1. The study assayed the expression of 2 pairs of stably transfected colorectal cancer cell lines: The CDX1 nonexpressing CRC cell line HCT116 was stably transfected with either CDX1 cDNA in the pRC/CMV expression vector (HCT116-CDX1) or with vector control (HCT116-Vec). The CDX1-expressing CRC cell line LS174T was similarly transfected with either a pSilencer vector containing a short sequence of CDX1 siRNA (LS174T-siRNA) , or a pSilencer vector containing a scrambled siRNA sequence as a control (LS174T-Vec).

2009-01-13 | GSE14380 | GEO

Transcription profiling of human colorectal cancer cell lines transfected with homeobox gene CDX1 cDNA to identfiy downstream targets

2009-01-23 | E-GEOD-14380 | biostudies-arrayexpress

Comparison of ectopic gene expression in Cdx1+/+ and Cdx1-/- thymic medullary epithelial cells

Project description:We have found that Cdx1 can promote ectopic gene expression in thymic epithelial cells. We isolated MHCIIhi CD80hi medullary thymic epithelial cells from Cdx1-/- and Cdx1+/+ and compare gene expression between the two subsets, also in the context of Cdx1-mediated changes in intestinal epithelial cells.

2018-05-01 | GSE68880 | GEO

Gene expression data and CDX1-binding sites in gastric epithelial cells

Project description:To identify the transcriptional targets of CDX1 underlying the metaplastic change, we explored genes affected by ectopic expression of CDX1 in gastric epithelial cells by combining expression microarray and ChIP-chip analyses.

2012-10-18 | GSE35369 | GEO

Identification of genes differentially expressed between control and EHF siRNA transfected HCT116 cells

Project description:we found that EHF allowed colon tumor cells to escape p53-mediated apoptosis.We performed microarray analysis to find the target genes of EHF. A colorecal cancer cell line HCT116 was transfected with an siRNA targeting EHF or negative control.

2010-07-29 | E-GEOD-22265 | biostudies-arrayexpress

MKN7_EB by EHF knockdown

Project description:MKN7_EB by EHF knockdown

| PRJNA689579 | ENA

Expression data from siRNA knockdown of Ehf in primary human corneal epithelial cells

Project description:Ehf is a transcriptional regulator that is highly expressed and enriched in corneal epithelium. To gain insights into the role of Ehf in the corneal epithelium, we performed siRNA knockdown of Ehf in primary human corneal epithelial cells. Primary human corneal epithelial cells were transfected with siEhf or si controls, plated, and harvested at 72 hr.

2013-01-01 | E-GEOD-43157 | biostudies-arrayexpress

Expression data from siRNA knockdown of Ehf in primary human corneal epithelial cells

2013-01-01 | GSE43157 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data