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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE202250 | GEO | 2025/05/03

REPOSITORIES: GEO

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq)

Project description:Mitotic entry correlates with remodeling of histone modifications, chromatin condensation, exclusion of transcription factors from the DNA and broad downregulation of transcription. However, whether mitotic condensation also influences interphase transcription is a question that has not been addressed yet. In this study, we reveal that loss of mitotic chromatin condensation results in a dramatic and spontaneous recruitment of the transcription machinery and unscheduled initiation of gene expression. This includes activation of inducible transcriptional programs, which occurs even in absence of relevant stimuli, such as the GAL system. Strikingly, such an erratic gene expression goes on after exit from mitosis. Thus, we reveal a novel function of mitotic chromosome condensation, i.e. resetting the transcriptome to prevent gene expression from drifting and maintain transcriptional homeostasis during interphase.

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ChIP-Seq)

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq I)

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq III)

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq II)

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Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase.

Project description:Mitotic entry correlates with the condensation of the chromosomes, changes in histone modifications, exclusion of transcription factors from DNA, and the broad downregulation of transcription. However, whether mitotic condensation influences transcription in the subsequent interphase is unknown. Here, we show that preventing one chromosome to condense during mitosis causes it to fail resetting of transcription. Rather, in the following interphase, the affected chromosome contains unusually high levels of the transcription machinery, resulting in abnormally high expression levels of genes in cis, including various transcription factors. This subsequently causes the activation of inducible transcriptional programs in trans, such as the GAL genes, even in the absence of the relevant stimuli. Thus, mitotic chromosome condensation exerts stringent control on interphase gene expression to ensure the maintenance of basic cellular functions and cell identity across cell divisions. Together, our study identifies the maintenance of transcriptional homeostasis during interphase as an unexpected function of mitosis and mitotic chromosome condensation.

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq)

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ChIP-Seq)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ChIP-Seq)

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Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq II)

Project description:Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq II)