Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatial sequencing of young and aged lungs following influenza A virus infection

ABSTRACT: Aging is known to alter the host repsonse to influenza infection. Here, we use 10x Visium spatial sequencing to identify spatial changes in mRNA expression of left lungs of young (16-week-old) and aged (80-week-old) mice following influenza infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE202322 | GEO | 2023/10/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

scRNA-seq of young and aged lungs following influenza A virus infection

Project description:Aging is known to alter the host repsonse to influenza infection. Here, we use single-cell RNA sequencing (scRNA-seq) to identify cellular changes in the lungs of young (16-week-old) and aged (80-week-old) mice following influenza infection.

2023-09-05 | GSE202325 | GEO

Bulk RNA-seq of young and aged lungs following influenza A virus infection

Project description:Aging is known to alter the host repsonse to influenza infection. Here, we use bulk RNA sequencing (bulk RNA-seq) to identify cellular changes in the lungs of young (16-week-old) and aged (80-week-old) mice following influenza infection.

2023-09-05 | GSE202324 | GEO

Bulk RNA-seq of young and aged livers following influenza A virus infection

Project description:Aging is known to alter the host repsonse to influenza infection. Here, we use bulk RNA sequencing (bulk RNA-seq) to identify cellular changes in the livers of young (16-week-old) and aged (80-week-old) mice following influenza infection.

2023-09-05 | GSE202323 | GEO

Gene expression profiles of young and aged endothelial cells isolated from the murine liver

Project description:To investigate the effect of aging on liver endothelial cells, we performed RNA sequencing of liver endothelial cells isolated from young (10-week-old) and aged (127-136 week-old) C57BL/6J mice.

2023-08-13 | GSE233052 | GEO

Hippocampal transcript profile in young and middle-aged mice

Project description:We carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze. Keywords: age comparison

2006-06-20 | GSE5078 | GEO

Single cell RNA sequencing of myeloid cells from lungs of young and aged mice

Project description:Single cell RNA sequencing from lungs of young (2-3 month old) and aged (20-22 month old) mice.

2021-10-20 | GSE167236 | GEO

Transcription profiling of chicken trachea on 1 and 4 week old birds infected by avian influenza virus.

Project description:Sylvia Reemers: age-related chicken in vivo infection: timecourse, 1wk ni= 1-week-old non infected, 1wk i= 1-week-old infected, 4wk ni= 4-week-old non infected, 4wk i= 4-week-old infected, Tissue type= Trachea. The aim of this study was to determine differences in host responses to avian influenza virus infection at host transcriptional level between 1- and 4-week-old birds.

2010-04-01 | E-TABM-772 | biostudies-arrayexpress

Transcription profiling of chicken lung on 1 and 4 week old birds infected by avian influenza virus.

Project description:Sylvia Reemers: age-related chicken in vivo infection: timecourse, 1wk ni= 1-week-old non infected, 1wk i= 1-week-old infected, 4wk ni= 4-week-old non infected, 4wk i= 4-week-old infected, Tissue type= Lung. The aim of this study was to determine differences in host responses to avian influenza virus infection at host transcriptional level between 1- and 4-week-old birds.

2010-04-01 | E-TABM-771 | biostudies-arrayexpress

Transcriptome profiling of lungs from young and aged hamster

Project description:Older age is one of the strongest risk factors for COVID-19 morbidity and mortality. Here, we sought to determine whether age-associated cellular senescence contributes to the severity of COVID-19 by studying the well-established golden hamster model of SARS-CoV-2-driven lung disease. We found that aged hamsters (22 months of age) accumulate senescent cells in the lungs and that the senolytic drug ABT-263 depletes these cells at baseline and during a SARS-CoV-2 infection. Relative to young hamsters (2 months of age), aged hamsters had a greater viral load during the acute phase of infection and displayed higher levels of sequelae during the post-acute phase. Interestingly, early treatment with ABT-263 was associated with a significantly lower pulmonary viral load, an effect associated with lower angiotensin converting enzyme 2, the receptor for SARS-CoV-2, and an amelioration of COVID-19-like lung disease in aged (but not young) animals. ABT-263 treatment of aged animals was also associated with lower pulmonary and systemic levels of senescence-associated secretory phenotype factors. Furthermore, early removal of senescent cells reduced the longer-term pulmonary inflammation. These data demonstrate the causative role of age-associated pre-existing senescent cells on the pathologic severity of experimental COVID-19.

2023-04-30 | GSE230301 | GEO

Altered transcriptional responses in the lungs of aged mice after influenza infection

Project description:This study used transcriptomic analysis to evaluate how aging specifically affects the functional host response to influenza in the mouse lung. Adult (12-16 weeks) and aged (72-76 weeks) female BALB/c mice were infected with influenza (A/Puerto Rico/8/34 (H1N1) (A/PR8)) intranasally (instilled with 50 μl of PBS containing 50-100 pfu PR8). Lungs were processed for RNA expression analysis via Agilent microarray at various time points. Time points were 0, 1, 3, 5, 7, 9 days post infection.

2022-06-21 | GSE197596 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data