Regulation of Parietal Cell Homeostasis by Bone Morphogenetic Protein signaling

ABSTRACT: Loss of BMP signaling in the stomach, achieved by transgenic expression of the BMP inhibitor noggin (H+/K+-Nog mice), causes parietal cells (PC) loss, SPEM, a marker of pre-neoplasia, and activation of cell proliferation. Purpose: We examined if specific inhibition of BMP signaling in PCs leads to aberrations in epithelial homeostasis

ORGANISM(S): Mus musculus

PROVIDER: GSE202355 | GEO | 2023/05/01

REPOSITORIES: GEO