Other

Dataset Information

0

Synergistic function screening of multiple checkpoint perturbation in TIL


ABSTRACT: A synergistic function screening system was established, in which a multiplexed CRIPSR knockout library targeting different checkpoint combinations was constructed and transduced into CD8+T cells to block multiple checkpoints in single cell. Based on this system, we performed a in vivo synergistic function screening of several checkpoints in tumor infiltrating CD8+T cells and find the best combined checkpoint blockade strategy to boost the CD8+T cell-mediated tumor elimination in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE202653 | GEO | 2022/06/15

REPOSITORIES: GEO

Similar Datasets

| PRJNA836888 | ENA
2012-08-24 | E-GEOD-33268 | biostudies-arrayexpress
2008-06-15 | E-GEOD-7469 | biostudies-arrayexpress
2007-09-01 | GSE8718 | GEO
2024-03-01 | GSE249969 | GEO
2024-03-01 | GSE249967 | GEO
2024-03-01 | GSE249971 | GEO
| PRJEB43664 | ENA
2016-01-04 | E-GEOD-70530 | biostudies-arrayexpress
2013-10-30 | E-GEOD-51849 | biostudies-arrayexpress