Dataset Information


Lgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin

ABSTRACT: Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, while contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell. Overall design: For the Lgr5 and Lgr6 stem cell comparison RNA was isolated from sorted GFPhi cell fractions of dorsal skin from Lgr5-EGFP-ires-CreERT2 mice and Lgr6-EGFP-ires-CreERT2, respectively (3 mice per group per sort).

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)

ORGANISM(S): Mus musculus  

SUBMITTER: Daniel E. Stange  

PROVIDER: GSE20269 | GEO | 2010-03-26



Similar Datasets

2010-03-25 | E-GEOD-20269 | ArrayExpress
2015-10-22 | E-MTAB-3533 | ArrayExpress
2017-05-16 | E-GEOD-62604 | ArrayExpress
2011-01-12 | GSE21568 | GEO
2011-01-12 | E-GEOD-21568 | ArrayExpress
2009-11-16 | E-MEXP-928 | ArrayExpress
2011-01-04 | E-GEOD-26393 | ArrayExpress
2011-01-04 | E-GEOD-26394 | ArrayExpress
2010-02-01 | GSE17485 | GEO
2011-10-03 | E-GEOD-32514 | ArrayExpress