Altered gene expression is associated with age-dependent memory impairment

ABSTRACT: The mechanisms underlying age-associated memory impairment are not well understood. We have shown that the onset of memory disturbances in the aging brain is associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation. To analyze if deregulated H4K12 acetylation impacts on learning-induced gene-expression required for memory consolidation we performed a high-density oligonucleotide microarray to compare the entire hippocampal gene-expression profile of 3 and 16-month-old mice during memory consolidation.

ORGANISM(S): Mus musculus

PROVIDER: GSE20270 | GEO | 2010/04/19

SECONDARY ACCESSION(S): PRJNA124135

REPOSITORIES: GEO