Spontaneous Endometritotic Lesions Compared to Eutopic Endometrium in the Baboon

ABSTRACT: The development and progression of endometriotic lesions are poorly understood, but immune cell dysfunction and inflammation are closely associated with the pathophysiology of endometriosis. A lack of suitable 3D in vitro models permitting the study of interactions between cell types and the microenvironment is a contributing factor. To address this limitation, we developed endometriotic organoids (EO) to explore the role of epithelial-stromal interactions and model peritoneal cell invasion associated with lesion development (GSE202661). These organoids were compared to spontaneous endometriotic lesions from baboons (Papio anubis).

ORGANISM(S): Papio anubis

PROVIDER: GSE202729 | GEO | 2022/06/15

REPOSITORIES: GEO