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NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE202778 | GEO | 2022/12/27

REPOSITORIES: GEO

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NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell differentiation [scRNA-seq]

Project description:Loss-of-function mutations of NOX1 is associated with inflammatory bowel disease (IBD). Mechanisms whereby loss of Nox1 drives IBD are incompletely defined. Here we used TNF⍺ treated colonoids to model IBD inflammation followed by single cell sequencing to get transcriptome profile of IBD relevant cells.

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NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell differentiation [RNA-seq organoid]

Project description:Loss-of-function mutations of NOX1 is associated with inflammatory bowel disease (IBD). In what epitheial cell types in human colon Nox1 is expressed is unclear. Here we performed RNA seq analysis of 50% WRN or 5% WRN treated human colonoid lines from IBD, UC and heathy donors. We showed Nox1 is mainly expressed in stem cell (50% WRN treated condition ) when comparing to coloncyte (5% WRN treated contion).

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