Long non-coding RNAs induced by TGF-beta in three breast (cancer) cell lines

ABSTRACT: Long non-coding RNAs (lncRNAs) are emerging as pivotal modulators of signaling trnasduction, and thereby regulate multiple pathological processes including cancer. TGF-beta signaling contributes to cancer metastasis by inducing epithelial-to-mesenchymal transition (EMT). To screen lncRNAs that are induced by TGF-beta, MCF10A-M1, MCF10A-M2 and MDA-MB-231 cells were stimulated with TGF-beta (5 ng/mL) fo 0 h, 2 h, 8 h and 24 h. RNA was extracted from those cells and analyzed by RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203119 | GEO | 2023/04/27

REPOSITORIES: GEO