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Astrocytic circadian clock control of energy expenditure by transcriptional stress responses in the ventromedial hypothalamus

ABSTRACT: Mice carrying a mutation which deletes Bmal1 in Gfap-expressing astrocytes, and control animals were fed either a standard diet or a high fat diet for 16 weeks. Conditional deletion of Bmal1 in Gfap cells decreased weight gain and increased energy expenditure under high fat diet, hence the transcriptome of Brown Adipose Tissue (BAT) and Ventromedial Hypothalamus (VMH) were obtained.

ORGANISM(S): Mus musculus

PROVIDER: GSE203125 | GEO | 2023/04/12

REPOSITORIES: GEO

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Single nucleus RNA-seq atlas of mouse ventromedial hypothalamus

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