Transcriptomics

Dataset Information

0

Secretogranin II influences the assembly and function of MHC class I in melanoma


ABSTRACT: Melanoma is the deadliest form of skin cancer showing rising incidence over the past years. New insights into the mechanisms of melanoma progression contributed to the development of novel treatment options, such as immunotherapies. However, acquiring resistance to treatment poses a big problem to therapy success. Therefore, understanding the mechanisms underlying resistance could improve therapy efficacy. By conducting transcriptional analysis between SCG2-overexpressing (OE) and control melanoma cells, we detected a downregulation of components of the antigen presenting machinery (APM), which is important for the assembly of the MHC class I complex.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203179 | GEO | 2023/03/16

REPOSITORIES: GEO

Similar Datasets

2021-11-26 | GSE174395 | GEO
2022-01-01 | GSE155537 | GEO
2022-01-15 | PXD030506 | Pride
2022-06-29 | GSE175975 | GEO
2012-12-31 | E-GEOD-31879 | biostudies-arrayexpress
2024-05-08 | GSE262779 | GEO
2023-01-01 | E-MTAB-11936 | biostudies-arrayexpress
2021-08-10 | ST001903 | MetabolomicsWorkbench
| PRJEB49824 | ENA
2023-12-01 | GSE229908 | GEO