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TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

ABSTRACT: To examine the functional significance of TRPV1 SUMOylation in vivo, we created a TRPV1K823R KI transgenic mouse line.We thus performed gene expression profiling analysis using data obtained from RNA-seq of the trigeminal ganglion of TRPV1K823R and control mouse models . Our analyses unveiled a role for TRPV1 SUMOylation in regulating gene networks related to the pain and itch pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE203197 | GEO | 2022/06/14

REPOSITORIES: GEO

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TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

Project description:TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

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