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A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-ALL

ABSTRACT: C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-DE-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the H4K12ac ChIP-seq epigenetic profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE203386 | GEO | 2022/12/08

REPOSITORIES: GEO

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