Genomics

Dataset Information

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Gene expression and SNP profiling discriminates chromophobe renal cell carcinoma and oncocytoma


ABSTRACT: Gene expression profiles, high-throughput SNP genotyping, and pathway analysis effectively distinguish chRCC from oncocytoma.  We have generated a novel transcript predictor that is able to discriminate between the two entities accurately, and which has been validated both in an internal and an independent data-set, implying generalizability.  A cytogenetic alteration, loss of chromosome 1p, common to renal oncocytoma and chRCC has been identified, providing the opportunities for identifying novel tumor suppressor genes and we have identified a series of immunohistochemical markers that are clinically useful in discriminating chRCC and oncocytoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20376 | GEO | 2011/02/02

SECONDARY ACCESSION(S): PRJNA125483

REPOSITORIES: GEO

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