Genomics

Dataset Information

0

Transcriptional response of Leptospira interrogans to iron limitation and characterization of putative Fur-like protein


ABSTRACT: Leptospirosis is a globally significant zoonotic disease caused by Leptospira spp. Iron is essential for growth of most bacterial species. Since availability of iron is low in the host, pathogens have evolved complex iron acquisition mechanisms to survive and establish infection. Virulence genes in some bacteria have been shown to be iron-regulated. In many bacteria, expression of iron-uptake and storage proteins is regulated by Fur. L. interrogans encodes four predicted Fur homologs; we have constructed a mutant in one of these, la1857. We conducted microarray analysis to identify differentially expressed genes in L. interrogans serovar Manilae grown under low iron compared with normal iron conditions found in EMJH medium. We also compared the transcriptional profile of the la1857 mutant versus wild-type Manilae under normal and low iron conditions.

ORGANISM(S): Leptospira interrogans

PROVIDER: GSE20422 | GEO | 2010/03/22

SECONDARY ACCESSION(S): PRJNA125587

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-20422 | biostudies-arrayexpress
2010-07-27 | GSE23173 | GEO
2010-07-27 | GSE23172 | GEO
| E-GEOD-23173 | biostudies-arrayexpress
| E-GEOD-23172 | biostudies-arrayexpress
2022-02-17 | PXD026044 | Pride
2010-03-31 | GSE17942 | GEO
| E-GEOD-53818 | biostudies-arrayexpress
2020-09-22 | GSE140019 | GEO
| PRJNA125587 | ENA