A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML

ABSTRACT: In the murine HoxA9/Meis1 (H9M) AML model leukemic stem cell (LSC) potential lies in three different heterogeneous immunophenotypes including Lin-cKit+ progenitor cells (Lin-), Gr1+CD11b+cKit+ myeloid cells and lymphoid cells (Lym+). We performed scRNA-seq to reveal the cell type contribution of HoxA9/Meis1 bone marrow and the hierarchical organization of different immunophenotypes. Therefore, primary and secondary bone marrow of HoxA9/Meis1 tranplanted animals were isolated, sorted and sequenced. We could identify that in the HoxA9/Meis1 AML model a pro-B cell population resides at the apex.

ORGANISM(S): Mus musculus

PROVIDER: GSE204676 | GEO | 2025/05/01

REPOSITORIES: GEO