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Transcriptomic analysis of murine lung tumor cells upon genetic KrasG12V ablation

ABSTRACT: To identify the mechanisms driving resistance upon KrasG12V ablation, we established lung cancer cell lines that carried loxP sequences flanking the exon 1 of Kras containing the G12V mutation (Kras +/loxG12Vlox), and lacked Trp53 alleles (Trp53 -/-). Tumor cells were infected with Adeno-Cre particles to excise the floxed sequences and individual cells that survived were expanded for further analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE204754 | GEO | 2023/03/05

REPOSITORIES: GEO

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