Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [pacBio WGS]

ABSTRACT: Numerous indirect, genetic approaches in various experimental systems have implicated dynamic alternative non-B DNA structures in human physiology and disease. Nevertheless, direct detection of dynamic DNA structures in vivo remains a challenge. To address this problem, we developed a new methods to visualize ssDNA containing alternative DNA structures. We described an uncharted landscape of dynamic alternative DNA structures formed by DNA cruciform and DNA triplexes (H-DNA) that contribute to genome instability.

ORGANISM(S): Homo sapiens

PROVIDER: GSE204806 | GEO | 2022/09/01

REPOSITORIES: GEO