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Transcriptomic changes from resulting from DARPP-32 modulation in breast cancer

ABSTRACT: DARPP-32 expression was reduced in oestrogen receptor positive luminal B breast cancer cells (T47D) using siRNA and control and DARPP-32 knockdown cells were subject to stimulation with estradiol17β (E2) or inhibition of protein kinase A (PKA) with PKA inhibitor fragment (6-22) amide prior to RNA sequencing. A bioinformatics pipeline of Trim Galore, Kallisto, DESeq2 and Qiagen Ingenuity Pathway Analysis was used for pathway analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE204836 | GEO | 2023/10/30

REPOSITORIES: GEO

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