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3D bioprinting of human liver models with biliary branching morphogenesis for hepatotoxicity, regeneration and NASH

ABSTRACT: The study of liver disease and drug discovery has been constrained by a lack of liver tissue with intrahepatic bile ducts (IHBD) network. Here we created functional bioprinting human liver with IHBD through precise temporal-spatial regulation via biochemical and mechanical cues. To investigate the regulatory mechanisms of the cell microenvironment of the human liver on the biliary branching morphogenesis, biomimetic liver tissue formation, and physiological function, transcriptome analysis of model A and model B was performed and compared with 2DD and PHH cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205179 | GEO | 2025/05/30

REPOSITORIES: GEO

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