Analysis of metabolic characteristics of peripheral blood mononuclear cells in patients with leukemia at the single cell level

ABSTRACT: We collected peripheral blood from leukemia patients at different stages, including those newly diagnosed as untreated, as well as those in remission on therapy, with a subset of samples including peripheral blood and bone marrow samples. First, mononuclear cells were isolated from the collected peripheral blood, followed by single-cell RNA sequencing and follow-up sequencing results for subgroup classification, focusing on changes such as glycolipid metabolism of B cells as well as T cells. The aim of this project was to explore the changes in metabolic remodeling in leukemia patients with the aid of single-cell technology to provide assistance in the diagnosis and treatment of the disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205219 | GEO | 2022/06/02

REPOSITORIES: GEO