Genomics

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Gene expression profiles of fibroblasts from MCT8 patients


ABSTRACT: Thyroid hormone is crucial for normal brain development. Thyroid hormone transporters control thyroid hormone homeostatis in brain. Mutations in the thyroid hormone transporter MCT8 result in a complex endocrine and neurological phenotype. We investigated the mechanisms of disease by analyzing gene expression profiles in fibroblasts from patients with mutations in MCT8. Performing comparative transcriptome analysis, we linked the genes differentially expressed in patient fibroblasts to the human brain transcriptome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20538 | GEO | 2010/08/23

SECONDARY ACCESSION(S): PRJNA125289

REPOSITORIES: GEO

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