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Satellite repeat RNA expression in epithelial ovarian cancer is linked to a tumor immunosuppressive phenotype

ABSTRACT: Repeatome profiling across ovarian, pancreatic, and colorectal cell lines identifies distinct clustering that is independent of tissue of origin highlighting differences in repeat co-expression patterns. Deeper analysis of ovarian cancer cell lines demonstrated that HSATII satellite repeat expression was highly associated with epithelial mesenchymal transition (EMT) and anti-correlated with interferon (IFN) response genes indicative of a more aggressive phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205430 | GEO | 2022/06/06

REPOSITORIES: GEO

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