Vorinostat treatment of PPS-ICBR cells

ABSTRACT: We generated immune checkpoint blockade resistant cell lines from a prostate tumor driven by Probasin-Cre Pten/P53/Smad4 loxp deletion, through serial implantation and ICB treatment. We then wanted to explore whether gene expression changes associated with resistance to immune checkpoint blockade could be reversed by treating ICB resistant cells with the pan-HDAC inhibitor Vorinostat. We used a microarray to determine gene expression changes caused by Vorinostat treatment in these cells with biological duplicates.

ORGANISM(S): Mus musculus Mus

PROVIDER: GSE205469 | GEO | 2024/02/13

REPOSITORIES: GEO