Mechanisms of drugs-resistance in small cell lung cancer II

ABSTRACT: Malignant transformation of SCLC often occurs simultaneously with the acquisition of chemotherapy resistance, suggesting that phenotypic malignant transformation is associated with adaptation to chemotherapy-induced stress. Recently, it has been reported that autophagy deficiency is involved in chemotherapy resistance in SCLC. To analyze gene expression changes associated with SCLC malignant transformation, we established ATG7 knockout and ATG7/SQSTM1 double knockout SCLC cell lines and performed RNA sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205522 | GEO | 2022/06/11

REPOSITORIES: GEO