Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of S4 treatment on glioma cells

ABSTRACT: S4, a sulfonamide drug, has been confirmed to induce apoptosis and autophagy in cancer cells. Immunogenic cell death is a special cell death type which is closely related to apoptosis and autophagy. We performed RNA-seq to determine the impact of S4 on global gene expression profile in LN229 cells. Our results show that S4 induces immunogenic cell death via the response to endoplasmic reticulum stress.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205538 | GEO | 2022/06/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Oligoadenylate synthetase-like (OASL) aggravated newcastle disease virus (NDV)-induced necroptosis in glioma cells

Project description:Newcastle disease virus (NDV) has emerged as an oncolytic agent in several cancers. Previous study has shown that NDV exerts cytolytic activity in glioma, however, the underlying mechanism has not been fully uncovered. Here the cytolytic activity of NDV in glioma and the associated mechanisms have been demonstrated. Infection with NDV inhibits cell proliferation and promotes cell apoptosis in LN229 cells. Further investigation showed that cytoplasmic organelle damage and cytoplasmic vacuolation were observed in LN229 cells after NDV infection. JC-1 staining assay proved that NDV caused cell apoptosis of LN229 cells by inducing mitochondrial dysfunction. We next speculated that NDV caused LN229 cells death through inducing necroptosis, but not ferroptosis, since the Fe2+ level did not alter after NDV infection. Furthermore, the NDV-caused cell death in LN229 cells was blocked by necroptosis inhibitor Nec1. Besides, RNA-seq analysis identified the different expression genes in NDV-infected LN229 cells. OASL, an antiviral gene, has been found to be directly induced by NDV infection. We also found that knockdown of OASL enhanced NDV infection-induced LN229 cells necroptosis. In summary, two aspects about cytolytic activity of NDV in glioma have been demonstrated. NDV presented cytolytic activity in glioma cells through inducing necroptosis. Additionally, targeting OASL may provide new strategy for enhancing necroptosis of glioma cells after NDV infection.

2023-05-01 | GSE227791 | GEO

Epichromatin HL-60/S4

Project description:Characterization of epichromatin by immunoprecipitation-DNA sequencing of formaldehyde-fixed and sonicated HL-60/S4 cells.

2015-12-31 | E-MTAB-2360 | biostudies-arrayexpress

TNF response in promyelocytic and granulocytic forms of HL60/S4 cells

Project description:The human promyelocytic cell line HL60/S4 can be differentiated into a granulocytic form with the addition of all-trans retinoic acid for 4 days. We investigated the conserved and differentiated responses to TNF in the granulocytic and promyelocytic forms of HL60/S4 cells.

2018-11-15 | GSE120579 | GEO

Pseudomonas sp. s4 strain:S4

Project description:Pseudomonas sp. s4 strain:S4 Genome sequencing

| PRJNA1201360 | ENA

Peribacillus sp. S4 strain:S4

Project description:Peribacillus sp. S4 strain:S4 Genome sequencing

| PRJNA1193798 | ENA

Nitrosopumilus sp. S4 strain:S4

Project description:Nitrosopumilus sp. S4 strain:S4 Genome sequencing

| PRJNA1398519 | ENA

Coxiella burnetii S4 strain:S4

Project description:Coxiella burnetii S4 strain:S4 Genome sequencing