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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [scRNA-seq]

ABSTRACT: CD44+ sorted lung samples from 7 bats in two 10X 3’ v3 libraries and separately gated cells

ORGANISM(S): Eonycteris spelaea

PROVIDER: GSE205768 | GEO | 2022/09/23

REPOSITORIES: GEO

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			Action	DRS
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	GSE205768_RAW.tar	Raw
	GSE205768_celltype_annotation_by_barcode.tsv.gz	Tabular
	filelist.txt	Txt

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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [Bulk RNA-seq]

Project description:CD44+ sorted lung samples from 7 bats in two 10X 3’ v3 libraries and separately gated cells

2022-09-23 | GSE205435 | GEO

Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus

Project description:Bats as the only flying mammals incur a high metabolic cost during extended powered flight, which results in febrile-like temperatures without injury. Herein, we investigate the in vivo heat shock response (HSR) in the cave nectar bat Eonycteris spelaea. We demonstrate that E. spelaea exhibits enhanced physiological heat resistance, marked by reduced lethality, tissue damage and serum corticosterone levels in comparison to mice upon heat challenge. Additionally, E. spelaea did not exhibit an acute transcriptional response observed heat stress in mice. Instead, bats displayed a delayed and non-canonical HSR that did not involve the activation of classical heat shock related genes and pathways. This altered response in E. spelaea is attributed to the elevated basal expression of heat shock proteins, which we demonstrate to be a common characteristic exhibited by bats from diverse sub-orders, families and diets. Taken together, we demonstrate a distinct HSR in E. spelaea relative to the conventional model organism, mouse, which may provide insights to understand novel regulatory targets and effector proteins that underlie the mammalian heat shock response.

2025-04-02 | GSE261939 | GEO

Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea).

Project description: Not available

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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-23 | GSE205770 | GEO

Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing.

Project description: Not available

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Transcriptomic profiling of bat immune responses (e. spelaea)

Project description:To examine the fundamental immunity in bats, particularly the status of their innate immune system in the basal healthy state, we profile Eonycteris spelaea bat tissue with Deep NGS coverage. This is coupled to a paired experiment where bats were stimulated in vivo with various PRR ligands to activate immune pathways.

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Generation of self-replicating airway organoids from the cave nectar bat <i>Eonycteris spelaea</i> as a model system for studying host-pathogen interactions in the bat airway epithelium.

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Increased viral tolerance mediates by antiviral RNA interference in bat cells

Project description:Bats harbor highly virulent viruses that can infect other mammals, including humans, posing questions about their immune tolerance mechanisms. Bat cells employ multiple strategies to limit virus replication and virus-induced immunopathology, but the coexistence of bats and fatal viruses remains poorly understood. Here, we investigated the antiviral RNA interference (RNAi) pathway in bat cells and discovered that they have an enhanced antiviral RNAi response, producing canonical viral small interfering RNAs (vsiRNAs) upon Sindbis virus (SINV) infection that were missing in human cells. Disruption of Dicer function resulted in increased viral load for three different RNA viruses in bat cells, indicating an interferon-independent antiviral pathway. Furthermore, our findings reveal the simultaneous engagement of Dicer and pattern-recognition receptors (PRRs), such as retinoic acid-inducible gene I (RIG-I), with double-stranded RNA, suggesting that Dicer attenuates the interferon response initiation in bat cells. These insights advance our comprehension of the distinctive strategies bats employ to coexist with viruses.

2024-07-12 | PXD053906 | Pride