IL-13Ra1-mediated signaling regulates ABC expansion and lupus pathogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE206012 | GEO | 2022/06/16
REPOSITORIES: GEO
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Project description:We report the application of RNA-seq, ATAC-seq, and CUT and RUN technology for high-throughput profiling of H3K27me3 epigenetic marks in mice SWAP-70 and DEF6 double knockout (DKO) B-lymphocytes (ABCs and FoBs) flow sorted from spleen. We show that ABCs from female and male DKO mice have unique transcriptional profiles, chromatin accessibility, and that there is a selective loss of repressive chromatin marks like H3K27me3 in ABCs of DKO females can contribute to the increased expression of X-chromosome linked genes like Tlr7 and several other loci among which Tbx21, the classical ABC marker, showed strongest loss in F-ABCs as compared to F-FoBs.
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Project description:IL-13Ra1-mediated signaling regulates ABC expansion and lupus pathogenesis
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