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Myeloid cell-expressed heme oxygenase-1 mitigates liver injury and fibrosis via the ligand of numb-protein X1 (LNX1)-Notch1 pathway

ABSTRACT: Activation of resident macrophages (Mf) and hepatic stellate cells in the perisinusoidal space is a key event in chronic liver injury. Under these circumstances, dysregulated innate immunity and inflammatory processes drive progressive accumulation of collagen, resulting in scarring and eventually, cirrhosis with life-threatening complications. In summary, by using RiboTag-based sequencing, we identified a novel regulatory LNX1/Notch1 pathway downstream of HO-1 that drives a protective form of M2 polarization of Mf and inhibits expansion of reactive cholangiocytes and liver fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE206069 | GEO | 2022/09/20

REPOSITORIES: GEO

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Identification of Cytoprotective Small Molecule Inducers of Heme Oxygenase-1

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Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages [RNA-Seq]

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