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Gonadal gap junctions activate Notch signaling to suppress intestinal innate immunity via p38/PMK-1 and lysosome pathway

ABSTRACT: We showed that the innexin genes encoding gap junction subunits positively regulated GLP-1/Notch signaling to suppress the innate immunity of C. elegans via PMK-1/p38 pathway. The unc-17 acts in the dowmstream of inx-14/glp-1 to regulate innate immunity.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE206090 | GEO | 2025/06/14

REPOSITORIES: GEO

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Gonadal gap junctions activate Notch signaling to suppress intestinal innate immunity via p38/PMK-1 and lysosome pathway II

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