MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

ABSTRACT: Purpose: The goals of this study are to compare NGS-derived retinal transcriptome profiling (RNA-seq) from WT and Wfs1-/- mices. Methods: Retinal mRNA profiles of 240-day-old wild-type (WT) and retina Wolframin knockout (Wfs1−/−) mice were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000. The sequence reads that passed quality filters were aligned to reference genome

ORGANISM(S): Mus musculus

PROVIDER: GSE206150 | GEO | 2023/01/04

REPOSITORIES: GEO