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Targeting ESR1 mutation-induced transcriptional addiction with BET inhibition

ABSTRACT: We investigated the therapeutic potential of BET inhibition to target ESR1 mutation-induced “transcriptional addiction” in ER-positive breast cancer. Our studies show that ESR1 mutant (Y537S and D538G) cells activate unique transcriptional programs that are targeted by OTX015, a BET inhibitor

ORGANISM(S): Homo sapiens

PROVIDER: GSE206185 | GEO | 2022/06/18

REPOSITORIES: GEO

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Targeting ESR1 mutation-induced transcriptional addiction with BET inhibition

Project description:Targeting ESR1 mutation-induced transcriptional addiction with BET inhibition

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