Single cell RNA seq of bone marrow cells from mouse MDS disease model and WT control

ABSTRACT: mDia1-miR146a double knockout (DKO) mice develop aging related MDS and eventually progress to AML at moribund stage. To investigate the rescue effect from IL6 deficiency, we created mDia1-miR146a-IL6 triple knockout (TKO) mice. Singel cell RNA seq was used to investigate the bone marrow cellularity change and pathway involved during the disease progression.

ORGANISM(S): Mus musculus

PROVIDER: GSE206600 | GEO | 2022/08/01

REPOSITORIES: GEO