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Multi-omic signatures of Chronic Beryllium Disease bronchoalveolar lavage cells relate to T cell function and innate immunity [Methylation]

ABSTRACT: We performed DNA methylation profiling between Chronic Beryllium Disease, beryllium-sensitized, and healthy control bronchoalveolar cells, and integration with gene expression and proteomic data

ORGANISM(S): Homo sapiens

PROVIDER: GSE206709 | GEO | 2023/06/20

REPOSITORIES: GEO

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Multi-omic signatures of Chronic Beryllium Disease bronchoalveolar lavage cells relate to T cell function and innate immunity [Expression]

Project description:We performed gene expression profiling between Chronic Beryllium Disease, beryllium-sensitized, and healthy control bronchoalveolar cells, and integration with methylation and proteomic data

2023-06-20 | GSE206715 | GEO

Multi-omic signatures of Chronic Beryllium Disease bronchoalveolar lavage cells relate to T cell function and innate immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-19 | GSE206719 | GEO

Characterization of bronchoalveolar lavage samples from two Be-exposed subjects

Project description:Chronic beryllium disease (CBD) is a metal-induced hypersensitivity disorder characterized by CD4+ T cell alveolitis. Single-cell gene expression profiling of bronchoalveolar lavage (BAL) cells focused on T cells may provide insight into unique subsets of CD4+ T cells, functional pathways, and/or molecules that could potentially be developed into novel therapeutics for treating CBD and other granulomatous lung diseases. To understand the unbiased cellular composition of airway associated CD4+ T cells in subjects with beryllium exposure, we used BAL cells from one beryllium-exposed (BeS) and one CBD subject diagnosed using previously defined criteria, and these two samples comprised the disease cohort.

2022-06-01 | GSE181174 | GEO

bronchoalveolar lavage fluid

Project description:bronchoalveolar lavage fluid Metagenome

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Workflow for metaproteome characterization in bronchoalveolar lavage fluid (BALF)

Project description:Establish a pipeline for identifying bacterial peptides from human bronchoalveolar lavage fluid samples.

2019-06-24 | PXD008273 | Pride

DNA methylation profiles of cells commonly found in bronchoalveolar lavage

Project description:Genome wide DNA methylation profiling of 4 cell populations purified from paediatic bronchoalveolar lavage samples. The cell types profiled are alveolar macrophages, granulocytes, lymphocytes and alveolar epithelial cells. Fluorescence-activated single cell sorting was used to purify the cell populations of interest using previously described methods (Shanthikumar, AJRCMB, 2020 ;63(2):152-159). Genome wide DNA methylation profiling was performed via the EPICArray. These data can be used for reference based deconvolution of cell proportion of bronchoalveolar lavage samples. DNA extracted from raw BAL (n=6) was also profiled using the EPICArray, allowing for validation of reference based deconvulution.

2021-10-09 | GSE185556 | GEO

Proteomic analysis of bronchoalveolar lavage fluid in COVID-19 patients

Project description:Proteomic analysis of bronchoalveolar lavage fluid in COVID-19 patients

2020-10-20 | PXD022085 | iProX

Transcription profiling of bronchoalveolar lavage cells from AJ mice treated with urethane vs. controls

Project description:AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis of bronchoalveolar lavage cells from control or urethane treated mice. A unique macrophage expression signature in the lung tumor microenvironment was able to correctly classify the lavage samples. Experiment Overall Design: RNA from bronchoalveolar lavage cells of age matched untreated AJ mice controls (C) or from urethane treated (T) AJ mice was prepared. Datasets were accurately classified using a unique macrophage gene expression signature derived from the tumor microenvironment.

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