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Longitudinal inflammatory gene expression associated with advanced myelofibrosis

ABSTRACT: Myelofibrosis (MF) is a progressive, bone marrow (BM) malignancy associated with monocytosis, and is believed to promote the pathological remodelling of the extracellular matrix. Here, we show that the pathologic grading of MF was associated with inflammatory gene expression in primary patient samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE206770 | GEO | 2022/07/11

REPOSITORIES: GEO

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Inflammatory gene expression associated with advanced myelofibrosis

Project description:Myelofibrosis (MF) is a progressive, bone marrow (BM) malignancy associated with monocytosis, and is believed to promote the pathological remodelling of the extracellular matrix. Here, we show that the pathologic grading of MF was associated with inflammatory gene expression in primary patient samples.

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RNA-seq analysis of Jak2-V617F monocytes in elastic versus viscous fibrotic matrix

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Viscoelastic properties of ECM differentially regulate monocyte patterns of gene expression

Project description:Myelofibrosis (MF) is a progressive, bone marrow (BM) malignancy associated with monocytosis, and is believed to promote the pathological remodelling of the extracellular matrix. Here, we show that the mechanical properties of MF, namely the liquid-to-solid properties (viscoelasticity) of BM, contribute to aberrant differentiation of monocytes. Human monocytes cultured in stiff, elastic hydrogels show pro-inflammatory polarization and differentiation towards dendritic cells, as opposed to those cultured in a viscoelastic matrix.

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MiR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2 [miRNA]

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Longitudinal inflammatory gene expression associated with advanced myelofibrosis

Project description:Longitudinal inflammatory gene expression associated with advanced myelofibrosis

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Project description:Inflammatory gene expression associated with advanced myelofibrosis

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