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MRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line

ABSTRACT: mRNA expression profile modified by stable transfection of microRNA mir-517a (MIR517A) in a human hepatocellular carcinoma cell line Huh-7 Keywords: Hepatocellular carcinoma, Expression array, microRNA

ORGANISM(S): Homo sapiens

PROVIDER: GSE20679 | GEO | 2011/02/17

SECONDARY ACCESSION(S): PRJNA129591

REPOSITORIES: GEO

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mRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line

Project description:mRNA expression profile modified by stable transfection of microRNA mir-517a (MIR517A) in a human hepatocellular carcinoma cell line Huh-7 Keywords: Hepatocellular carcinoma, Expression array, microRNA microRNA mir-517a (MIR517A) was transfected to Huh-7 cells using GFP-expressing lentiviral vector. Infected cells were selected using flow cytometry and subjected to mRNA expression microarray experiment. The profiles were compared to controls cells infected with only GFP protein.

2011-02-17 | E-GEOD-20679 | biostudies-arrayexpress

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

Project description:MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

| PRJNA124713 | ENA

Homo sapiens

Project description:mRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line

| PRJNA129591 | ENA

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

Project description:Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor due to activation of multiple cellular pathways and molecular alterations. Herein, we report the first molecular classification of 89 HCC based on the expression of 358 microRNAs and integrative genomic analysis. Three main subclasses of HCC were identified : two of them were associated with beta-catenin mutations or aggressive phenotype. A subset of the subclass of aggressive tumors (8/89, 9%) showed overexpression of a cluster of microRNAs located on chr19q13.41 (C19MC locus. We showed that miR 517a, representing C19MC, promoted cell proliferation, migration and invasion in vitro and induced the development of aggressive tumors in vivo suggesting its role as a novel oncogenic driver in HCC. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2011-02-17 | E-GEOD-20596 | biostudies-arrayexpress

microRNA profiling of human healthy liver and hepatocellular carcinoma

Project description:microRNA profiling of 10 human healthy liver and 9 human hepatocellular carcinoma tissues using bead-based technology microRNA expression profiling was performed using freshly frozen healthy liver and hepatocellular carcinoma tissues obtained at the time of surgical treatment. keywords: healthy liver, hepatocellular carcinoma, expression array, microRNA

2012-07-21 | E-GEOD-31383 | biostudies-arrayexpress

microRNA profiling of human hepatocellular carcinoma

Project description:microRNA profiling of 89 human hepatocellular carcinoma tissues using bead-based technology. microRNA expression profiling was performed using freshly frozen hepatocellular carcinoma tissues obtained at the time of surgical treatment.

2011-02-17 | E-GEOD-20594 | biostudies-arrayexpress

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

2011-02-17 | GSE20596 | GEO

Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas

Project description:The gastric adenocarcinoma cell line HGC-27 and colorectal adenocarcinoma cell line HCT-8 cells were grown in Roswell Park Memorial Institute (RPMI) 1640 medium (Hyclone, Logan, UT, USA.). The human hepatocellular carcinoma cell lines HepG2 and Huh-7 were cultured in Dulbecco’s modified Eagle's medium (DMEM) (Hyclone, Logan, UT, USA.).

2019-06-04 | GSE132119 | GEO

microRNA profiling of human hepatocellular carcinoma

Project description:microRNA profiling of 89 human hepatocellular carcinoma tissues using bead-based technology.

2011-02-17 | GSE20594 | GEO

Transient transfection of miR-449 family in the hepatocellular carcinoma cell line HLE

Project description:In this study, we comparatively analyzed the members of the miR-449 family (miR-449a, miR-449b, and miR-449c) with regards to their target genes and functional effects in hepatocellular carcinoma (HCC). Microarray analysis after transient transfection of miR-449a, miR-449b, and/or miR-449c in the HCC cell line HLE identified putative target genes of miR-449a, miR-449b, and miR-449c.

2015-11-06 | GSE74710 | GEO

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