Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Arid5b overexpression on the B cell development

ABSTRACT: To investigate the role of Arid5b in B cell development, we established a mouse model with overexpression of Arid5b driven by Vav1

ORGANISM(S): Mus musculus

PROVIDER: GSE206805 | GEO | 2022/08/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Effect of Arid5b overexpression on the B cell development

Project description:Effect of Arid5b overexpression on the B cell development

| PRJNA852231 | ENA

Leukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [CUT&Run]

Project description:We employed a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a repressor complex. The former localizes to active regions of the genome, tethering HDAC1 and HDAC2 to enhancers and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell-specific signaling.

2026-05-19 | GSE297398 | GEO

Leukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [RNA-Seq]

2026-05-19 | GSE297397 | GEO

Molecular mechanisms of ARID5B-mediated genetic susceptibility to acute lymphoblastic leukemia

Project description:There is growing evidence for the inherited basis of susceptibility to childhood acute lymphoblastic leukemia (ALL). Genome-wide association studies have identified non-coding ALL risk variants at the ARID5B gene locus, but their exact functional effects and the molecular mechanism linking ARID5B to B-ALL leukemogenesis remain largely unknown. In this study, by targeted sequencing in germline DNA of 5,008 children with ALL, we identified 31 common variants in ARID5B significantly associated with leukemia risk, all of which were non-coding. Six cis-regulatory elements at the ARID5B locus were discovered using CRISPR-based high-throughput enhancer screening. Strikingly, the top ALL risk variant (rs7090445, P=1.82×10-10) is located precisely within the strongest enhancer element, which is also distally tethered to the ARID5B promoter. The rs7090445 variant allele disrupts the MEF2C binding motif sequence, resulting in reduced MEF2C affinity and decreased local chromosome accessibility. MEF2C influences ARID5B expression in ALL, likely via a transcription factor complex with RUNX1. Using the UK Biobank dataset (n=349,861), we showed that rs7090445 was also associated with lymphocyte percentage and count in the general population (P=8.6×10-22 and 2.1×10-18, respectively). Taken together, our results indicate that ALL risk variants in ARID5B function by modulating cis-regulatory elements at this locus.

2022-08-11 | GSE195831 | GEO

Defining the interactome of ARID5B by AviTag protein pull-down coupled to quantitative mass spectrometry.

Project description:Among the strongest associations with pediatric B-cell acute lymphoblastic leukemia (B-ALL) are risk non-coding variants localized in the intron of ARID5B (AT-rich interaction domain 5B), a poorly characterized DNA-binding protein. In this study, we defined the interactome of ARID5B by LC-MS/MS and identified transcriptional repressors HDAC1, HDAC2, MIER1 and C16ORF87 as interactors. Structural predictions revealed that ARID5B and its interactors assemble into a repressor complex. We further validated and characterized the molecular function of the ARID5B repressor complex in B cells.

2026-05-19 | PXD061867 | Pride

Oncogenic roles of ARID5B in T-ALL

Project description:Oncogenic roles of ARID5B in T-ALL

| PRJNA382148 | ENA

Effect of overexpression of EPIC1 on gene expression in MCF7 cells [RNA-seq I]

Project description:To investigate and determine the role of EPIC1 overexpression in cancer cells, we established EPIC1 overexpressing MCF7 stable cells.

2025-06-10 | GSE229721 | GEO

Effect of IGF2BP3 in the development of glioma

Project description:To investigate the function IGF2BP3 in the regulation of tumor occurrence and development, we established 4 U87MG cell lines in which IGF2BP3 gene has been knocked out and overexpression.

2023-06-29 | GSE235828 | GEO

The effect of overexpression of ITGA2B on cellular hypoxia tolerance

Project description:A total of four groups were established, including the normal control group, ITGA2B overexpression group, hypoxic culture control group, and hypoxic culture ITGA2B overexpression group.

2025-03-28 | PXD048442 |

Effect of depletion or transgenic overexpression of nup133 or elys on zygotic genome activation (ZGA) during zebrafish early development

Project description:To investigate the function of nuclear pore complex (NPC) in the regulation of zygotic genome activation (ZGA), we established mutants of nucleoporins, including maternal and zygotic mutant of nup133 (MZnup133) and maternal mutant of elys (Melys), for maternal depletion by CRISPR/Cas9, and transgenic embryos of nup133 (Tgnup133) for maternal overexpression through Tol2 mediated method. We then performed gene expression profiling analysis using data obtained from RNA-seq of wildtype, MZnup133, Melys and Tgnup133 at three time points.

2023-02-22 | GSE212933 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data