Reduced PGC-1α expression and mitochondrial biogenesis predisposes gliomas to radiation resistance

ABSTRACT: To investigate the role of mitochondrial metabolic pathways in glioma radioresistance, we established the radioresistant (RR) glioblastoma (GBM) cells in vitro and collected 2 self-pairs of primary and recurrent GBM samples. We then performed gene expression profiling analysis using data obtained from RNA-seq of GBM cells and tissue samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE206917 | GEO | 2023/06/01

REPOSITORIES: GEO