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Effect of IVIG on the activation of plasmacytoid dendritic cells

ABSTRACT: To investigate the effect of IVIG and desialylated IVIG on the activation of plasmacytoid dendritic cells (pDCs). Human primary plasmacytoid dendritic cells were treated with TLR stimulation together with or without IVIG or desialylated IVIG, and the change of genes were analyzed. Primary human pDCs were preincubated with or without 10mg/ml IVIG or desialylated IVIG followed by stimulation with CpG overnight. The different genes between IVIG+CpG and desialylated IVIG+CpG were analyzed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207028 | GEO | 2022/07/04

REPOSITORIES: GEO

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