Transcriptomics

Dataset Information

0

CROPSeq of Putative AD- and PSP-associated cis-Regulatory Regions in iPSC-derived Neurons and Microglia


ABSTRACT: We performed a pooled CRISPRi screen (CROP-seq) and genome editing to validate 19 genetic variants prioritized from massively parallel reporter assays to screen 5,706 polymorphisms from genome-wide association studies for both Alzheimer’s disease (AD) and Progressive Supranuclear Palsy (PSP) across 11 distinct loci. This allowed us to pinpoint regulatory targets in a cell-type specific manner.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207099 | GEO | 2022/07/05

REPOSITORIES: GEO

Similar Datasets

2011-11-23 | E-GEOD-32037 | biostudies-arrayexpress
2011-11-23 | E-GEOD-32040 | biostudies-arrayexpress
2011-11-23 | E-GEOD-32039 | biostudies-arrayexpress
| PRJNA305114 | ENA
2012-12-01 | E-GEOD-34287 | biostudies-arrayexpress
2024-04-08 | GSE255904 | GEO
2024-04-08 | GSE255902 | GEO
2014-06-01 | E-GEOD-53740 | biostudies-arrayexpress
2022-02-15 | PXD011446 | Pride
2022-12-08 | PXD031648 | Pride