Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207114 | GEO | 2022/10/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta.

Project description: Not available

| S-EPMC9546589 | biostudies-literature

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [RNA-seq]

Project description:Mammalian sex chromosomes encode homologous X/Y gene pairs that were retained on the male Y and escape X chromosome inactivation (XCI) in females. Inferred to reflect X/Y-pair dosage sensitivity, monosomy X is a leading cause of miscarriage in humans with near full penetrance. This phenotype is shared with many other mammals but not the mouse, which offers sophisticated genetic tools to generate sex chromosomal aneuploidy but also tolerates its developmental impact. To address this critical gap, we generated X-monosomic human induced pluripotent stem cells (hiPSCs) alongside otherwise isogenic euploid controls from male and female mosaic samples. Phased genomic variants of these hiPSC panels enable systematic investigation of X/Y dosage-sensitive features using in vitro models of human development. Here, we demonstrate the utility of these validated hiPSC lines to test how X/Y-linked gene dosage impacts a widely-used model for the human syncytiotrophoblast. While these isogenic panels trigger a GATA2/3 and TFAP2A/C -driven trophoblast gene circuit irrespective of karyotype, differential expression implicates monosomy X in altered levels of placental genes, and in secretion of placental growth factor (PlGF) and human chorionic gonadotropin (hCG). Remarkably, weighted gene co-expression network modules that significantly reflect these changes are also preserved in first-trimester chorionic villi and term placenta. Our results suggest monosomy X may skew trophoblast cell type composition and function, and that the compound haploinsufficiency of the pseudoautosomal region likely plays a key role in these changes.

2022-10-04 | GSE207109 | GEO

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [CytoSNP-850k]

2022-10-04 | GSE207107 | GEO

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [Infinium methylEPIC]

2022-10-04 | GSE207108 | GEO

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [RNA-seq TBL]

2022-10-04 | GSE207112 | GEO

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

Project description:Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

| PRJNA853743 | ENA

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [RNA-seq]

Project description:Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [RNA-seq]

| PRJNA853752 | ENA

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [Infinium methylEPIC]

Project description:Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [Infinium methylEPIC]

| PRJNA853753 | ENA

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [CytoSNP-850k]

Project description:Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [CytoSNP-850k]

| PRJNA853754 | ENA

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [RNA-seq TBL]

Project description:Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta [RNA-seq TBL]

| PRJNA853751 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data