Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

ABSTRACT: Regulation of global transcription output is important for normal development and disease but only few regulators of the process are known. Here, we describe DNA topoisomerase I (TOP1) as a novel regulator where it exerts transcriptional repression to prevent transcription overdrive. This function requires a conserved secondary DNA binding surface that is distinct from its catalytic pocket.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE207163 | GEO | 2023/05/29

REPOSITORIES: GEO