BET inhibition induces synthetic lethality in BRCA2-deficient pancreatic cancer via autophagy-dependent cell death [CUT&RUN]

ABSTRACT: To model familial pancreatic cancer patients, we generated isogenic Brca2 deficient pancreatic cancer cell lines with CRISPR/Cas9. To investigate the changes in the enhancer landscape upon BET inhibition, we performed H3K27ac CUT-and-RUN-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE207296 | GEO | 2023/09/21

REPOSITORIES: GEO